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Metastasis, the dissemination of cells from the primary tumor to other sites within the body, is responsible for 90% of deaths linked to cancer. Chemotherapy is the standard of care for metastatic breast cancer, although many patients do not respond well or develop resistance to these drugs. The goal of our research is to understand the contribution of the components that surround and support tumors in these processes, in particular the extracellular matrix, to better predict which tumors will metastasize and become drug-resistant, as well as find new ways to treat them.
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Madeleine Oudin, PI
Photo by Samara Vise 
Image by Sammy Kata
Lab FUNDING
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NEWSMay 2021
Congratulations to post-doctoral fellow Samantha Payne who has obtained a tenure-track position at the University of Guelph! Congratulations to the Oudin Lab members graduating this year! Masters students Priyanka Ram, Logan Rubio, Priyanka Ram, and undergraduates Sara Blake, Nina Pittas and Sarah Mackin. Best of luck for the future!! 
April 2021
Madeleine presents at the BEIS 2021 meeting on engineered models to study the role of the innervation in breast cancer. Congratulations to undergraduate researcher Rachel McGinn who has been selected as a 2021 Barry Goldwater Scholar! Story here. New preprint! Check out our paper on chemotherapy-induced collagen IV driving cancer cell invasion through the activation of FAK/Src signaling led by Jackson Fatherree here. New preprint! Check out our paper on potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer led by post-doc Sam Payne in collaboration with the Levin lab found here. March 2021 The Oudin Lab welcomes new lab member Margot Burge, Madeleine's daughter born March 17th, 2021. Congratulations to undergraduate researcher Deepti Srinivasan, who was selected as a 2021 Laidlaw Scholar! She will be working on the role of bioelectricity and electrical fields in breast cancer invasion. Congratulations to undergraduate researcher Diamond Mensah, who was selected as a 2021 Tufts Summer Scholar! She will be working with PhD student Sydney on the role of adipocyte-secreted Collagen VI in tumor cell invasion. Madeleine presents the lab's research on the role of the tumor microenvironment in treatment resistance at the Sanford Burnham Prebys Medical Research Institute Seminar Series. Video here! New publication! Will participated in a collaborative study with the Black Lab analyzing RNAseq data from cardiac fibroblasts of different ages. The paper is on BioRxiv here. February 2021 Congratulations to Logan Rubio and Madeleine for being voted Exemplary Engineers by BEaCHes! 
Madeleine and Sam Payne present their research in the Cell Migration Seminars.
December 2020
Happy holidays from the Oudin Lab! 
Priyanka Ram does her 3-minute thesis presentation at the Northeastern Association of Graduate Schools Thesis competition!
November 2020 Exciting week for the Oudin lab: - Madeleine present at the annual MIT Path of Professorship workshop on how to negotiate your startup for an academic faculty position - Jackson is a finalist for the ASMB Iozzo Trainee award and will be presenting at the E-Symposia on Thursday Nov 12th - MSc student Victory is presenting a poster at the ABRCMS meeting - Former MSc student Janani is presenting her research at the Systems Approaches to Cancer Biology meeting Congratulations to Priyanka Ram, who won first place at the 3min thesis competition organized by the Graduate Student Council at Tufts! October 2020 
Paper out at Science Advances! See here for our newest study led by Andrew Wishart titled 'Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis'. Tufts Now also covered the paper. So proud of everyone's hard work on this!
Madeleine attends BMES 2020 represented the Tufts BME department and presented the lab's work on decellularized ECM matrices to study invasion and metastasis. Sarah Blake joins the lab as a part of the Louis Stokes Alliances for Minority Participation Program Justinne Guarin gives a talk at the NYAS Systemic Effects of Metastatic Cancer meeting on her work on the effect of chemotherapy on the liver ECM. She was also awarded a School of Engineering Travel Award to attend this meeting. Sydney Conner is appointed to the NIIDDK T32 Research Training Program in Nutrition,Obesity, and Metabolic Disorders for her work on studying adipocyte-driven ECM secretion. September 2020 The Oudin lab goes apple picking! 
August 2020
Madeleine is invited to present the lab's research in the Pre-Tenure Bioengineering Faculty e-Seminar Series. 
Welcome to new post-doctoral fellow Allison Sirois, who is starting in the lab as an NIH IRACDA Post-doctoral scholar! She will will look at the role of innervation in breast cancer.
Paper accepted!! Wishart et al., 2020, currently on Biorxiv, has been accepted for publication at Science Advances! Final version should be out soon! Congratulations to MSc student Priyanka for passing her ORP with flying colors! She will be working on targeting bio electricity to treat metastatic breast cancer. The lab welcomes a new post-doctoral fellow Charlotte Kelley, who recently completed her PhD with Prof. Erin Cram at Northeastern. Charlotte will look into ECM-driven mechanisms of metastasis. Welcome Charlotte! Madeleine has been invited to share recent work from the lab at the ASMB E-Symposium 'Matrix: the Master Puppeteer'. Jackson presents his work on 'Paclitaxel-induced Collagen IV drives TNBC cell migration in the post-chemotherapy tumor microenvironment' at the CSHL meeting on Models and Mechanisms of Cancer. July 2020 The lab says goodbye to Janani Baskaran, who after completing her BSc and MSc at Tufts BME is off to Yale for her PhD. We will miss her but wish her the best for her graduate studies! Madeleine gives talks to the incoming BEST freshman students who will be freshmen in the fall at Tufts, to the DIAMONDs Scholars Program, University College participants who are high schoolers from all over the world. Happy Bastille Day! Madeleine is French as well so we did the same for Bastille Day!! 
Happy Canada Day! Sam and Madeleine are both Canadian, so we decided to have a little celebration with a Kahoot quiz to test the knowledge of our lab members about Canada!
June 2020
Congratulations to 2nd year PhD student Justinne for passing her original research proposal! A few lab members got together to celebrate in person - socially distanced and wearing masks - and have ice cream! 
Congratulations to 2nd year PhD student Sydney for passing her original research proposal!
We welcome Priyanka Ram as a new MSc student in the lab.
The Oudin Lab has been approved from reopening! Even though we have been at home for almost 3 months, we have been keeping busy. See what we have been up to from 9-5 during COVID:https://youtu.be/aPIvObXEamw All lab members participate, but special thanks to Victory who put it all together! |