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Metastasis, the dissemination of cells from the primary tumor to other sites within the body, is responsible for 90% of deaths linked to cancer. Chemotherapy is the standard of care for metastatic breast cancer, although many patients do not respond well or develop resistance to these drugs. The goal of our research is to understand the contribution of the components that surround and support tumors in these processes, in particular the extracellular matrix, to better predict which tumors will metastasize and become drug-resistant, as well as find new ways to treat them.
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WE ARE HIRING!
- Research Technician: This lab technician job exists to assist in the daily lab maintenance and research support tasks for several research projects investigating the role of neuronal genes and nerves in breast cancer progression, Bachelors degree in biology or related field required, lab experience a plus. Please apply through link.
- Postdoctoral fellows: We are looking for 2 two-postdoctoral fellows, in the area of neurogenesis in tumors and bioelectricity. See here for more info.
- Research Technician: This lab technician job exists to assist in the daily lab maintenance and research support tasks for several research projects investigating the role of neuronal genes and nerves in breast cancer progression, Bachelors degree in biology or related field required, lab experience a plus. Please apply through link.
- Postdoctoral fellows: We are looking for 2 two-postdoctoral fellows, in the area of neurogenesis in tumors and bioelectricity. See here for more info.
Madeleine Oudin, PI
Photo by Samara Vise 
Image by Sammy Kata
Lab FUNDING
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NEWSDecember 2021
Paper out! Our paper describing the role of potassium-channel driven hyperpolarization in breast cancer metastasis led by former postdoc Sam Payne is out at Ebiomedicine! New pre-print describing the role of sensory nerves in TNBC migration and metastasis. See here! November 2021 We welcome Ken Salhany as a new member of the lab, who will be working on as a research technician on the ECM-related projects. We say goodbye to our first rotation student Wendelin and welcome our second rotation student from CMDB Haley Dame, who will be working with Will Le on the neuronal project. Madeleine gave a seminar titled 'Dissecting and targeting the neuronal and bioelectrical properties of cancer cells' at the UNC Lineberger Cancer Center. Thanks to Prof. Jim Bear for the invitation! October 2021 We say goodbye to postdoc Charlotte Kelley as she moves on to a new position at Sai Life Sciences. We wish you all the best and will miss you! The Oudin lab goes apple picking! 
Rachel McGinn presents her research at BMES in Orlando.
October 2021
The Oudin Lab has been awarded a DP2 NIH New Innovator Award to dissect the neuronal identity of tumors. See the NIH press release and Tufts Now story. September 2021 We welcome Wendelin Marmol to the lab for her first rotation as part of the CMDB program! We welcome Atef Fayed, pursuing a research project in the lab for his MSc in Biology degree. We are hiring post-doctoral researchers in both areas of the lab - the role of the ECM in chemoresistance and chemotherapy-induced metastasis and dissecting the neuronal identity of tumors. Please email Madeleine with your CV explaining your background and why you are interested in the lab. August 2021 Congratulations to Justinne who was selected for a Life Science Consulting Fellowship at Alacrita Consulting! End of the summer presentation by Gantcher Summer Scholar Diamond! Great work Diamond! 
July 2021
The lab comes together to say goodbye to post-doctoral fellow Sam, who is moving on to start her own lab in Canada! We will miss you Sam but wish you all the best! 
Paper accepted! Our collaboration with the Black Lab involving graduate student Will Le has been accepted for publication at Physiological Genomics. Congrats to first author Luke Perreault! Oudin Lab summer BBQ! Great to hang out with lab members, partners and friends and play some corn hole! 
Oudin Lab summer 2021! 
June 2021
Congratulations to Justinne Guarin, who was named a 2021 SMDP Biotech Scholar! May 2021 Congratulations to post-doctoral fellow Samantha Payne who has obtained a tenure-track position at the University of Guelph! Congratulations to the Oudin Lab members graduating this year! Masters students Priyanka Ram, Logan Rubio, Priyanka Ram, and undergraduates Sara Blake, Nina Pittas and Sarah Mackin. Best of luck for the future!! 
April 2021
Madeleine presents at the BEIS 2021 meeting on engineered models to study the role of the innervation in breast cancer. Congratulations to undergraduate researcher Rachel McGinn who has been selected as a 2021 Barry Goldwater Scholar! Story here. New preprint! Check out our paper on chemotherapy-induced collagen IV driving cancer cell invasion through the activation of FAK/Src signaling led by Jackson Fatherree here. New preprint! Check out our paper on potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer led by post-doc Sam Payne in collaboration with the Levin lab found here. March 2021 The Oudin Lab welcomes new lab member Margot Burge, Madeleine's daughter born March 17th, 2021. Congratulations to undergraduate researcher Deepti Srinivasan, who was selected as a 2021 Laidlaw Scholar! She will be working on the role of bioelectricity and electrical fields in breast cancer invasion. Congratulations to undergraduate researcher Diamond Mensah, who was selected as a 2021 Tufts Summer Scholar! She will be working with PhD student Sydney on the role of adipocyte-secreted Collagen VI in tumor cell invasion. Madeleine presents the lab's research on the role of the tumor microenvironment in treatment resistance at the Sanford Burnham Prebys Medical Research Institute Seminar Series. Video here! New publication! Will participated in a collaborative study with the Black Lab analyzing RNAseq data from cardiac fibroblasts of different ages. The paper is on BioRxiv here. February 2021 Madeleine and Sam Payne present their research in the Cell Migration Seminars. Congratulations to Logan Rubio and Madeleine for being voted Exemplary Engineers by BEaCHes! 
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