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Metastasis, the dissemination of cells from the primary tumor to other sites within the body, is responsible for 90% of deaths linked to cancer. Chemotherapy is the standard of care for metastatic breast cancer, although many patients do not respond well or develop resistance to these drugs. The goal of our research is to understand the contribution of the components that surround and support tumors in these processes, in particular the extracellular matrix, to better predict which tumors will metastasize and become drug-resistant, as well as find new ways to treat them.
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Madeleine Oudin, PI
Photo by Samara Vise Lab FUNDING
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NEWSMay 2020
Graduation Tufts 2020! We had a great weekend celebrate the class of 2020 with special shoutout to our Oudin Lab graduates: Joanna Peng, graduating with degree in Chemical Engineering, Claire Dunn, graduating with a degree in Biology, Janani Baskaran, graduating with a Msc in Biomedical Engineering, our senior design team Marguerite Salamone, Risa Williams and Blake McIntyre graduating from Biomedical Engineering. Zoom happy hour and games, online ceremony and gift delivery! Thank you for all your contributions to the Oudin Lab!! 
Our ECM prediction paper is out in APL Bioengineering! Check it out here. This is the first ECM paper from the lab! April 2020 Madeleine had a 'virtual visit' at Penn State College of Medicine and gave a virtual seminar for the Biomedical Science Seminar Series on the lab's work on the role of the ECM in metastasis and drugs resistance. Thanks to Katherine Aird for the invitation. Congratulations to Victory and Logan for passing their Original Research Proposal exams for their Masters Thesis with flying colors! Congratulations to Oudin Lab undergrads who are moving on graduate school: Janani Baskaran will be going to Yale BME, Joanna Peng will be going to BU BME and Anna Weldy will be going to UC Berkeley CHEME! Congratulations to sophomore Rachel McGinn who has been selected as a 2020 Laidlaw Scholar! This funding will support her for 2 summers to develop her research and leadership skills. Congratulations to Janani on a successful Masters thesis defense on her work entitled 'Predicting Breast Cancer Invasion in Response to Extracellular Matrix Cues'. We did our best to celebrate by Zoom and can't wait for an in person celebration. 
March 2020
The Oudin lab is officially shut down for the COVID-19 pandemic. Stay safe everyone! Will and Sydney presented their research at the Annual Graduate Student Research Symposium. Congrats to Will for his first prize in the 3-min talk! 
February 2020
Madeleine visited Tufts Medical School to share work from the Oudin Lab on the neural identity of tumors. Madeleine was named an Exemplary Engineering by the graduate students at Tufts BME for the second year in a row! Thanks to the students for their support!! 
Madeleine visited the Biomedical Engineering Department at UConn in Storrs, CT to share work from the Oudin Lab on the roles of the ECM in driving metastasis.
The lab goes downtown to see Jackson's annual talk for the CMDB PhD program and went for hotpot in Chinatown after. 
We welcome new Masters student Victory Unigwe to the lab! She will investigate the mechanisms by which chemotherapy treatment alters ECM composition in breast tumors.
The lab took Madeleine out for lunch in Harvard Square to celebrate her birthday! Thanks everyone! 
January 2020
Pre-print submitted! We are excited to share a pre-print from the lab entitled 'Obesity driven changes in ECM composition promote local invasion and metastasis of breast tumors' work led by 1st Oudin Lab member Andrew Wishart, with help from Yifan Peng, Justinne Guarin, Sydney Conner, Jackson Fatherree and collaboration with Andrew Greenberg's lab at the HNRCA. Madeleine visits the Randall Centre for Cell and Molecular Biophysics to share the lab's research. Thanks to Matthias Krause, fellow Gertler lab alum, for hosting! 
Happy New Year and happy 2nd birthday to us!
We started the New Year with a lot of exciting news. Grant Awarded! The Oudin Lab has been awarded an Early Career Investigator Award from the METAvivor Metastatic Breast Cancer Foundation. We are grateful for their support. Pre-print submitted! We are excited to share a pre-print from the lab entitled 'Cell shape, and not 2D migration, predicts ECM-driven 3D cell invasion in breast cancer', worked led by MSc student Janani Baskaran and NSF REU summer student Anna Weldy, to which many lab members contributed. Madeleine presented work from the lab at the CMBE-BMES Annual meeting in Puerto Rico, where she received a Rising Star Award. 
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